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Regardless, the extent of absorption isn't noticed to get significantly affected since the recorded AUC decreased by only about 11 % .

Nitric oxide then activates the enzyme guanylate cyclase, which ends up in enhanced amounts of cyclic guanosine monophosphate (cGMP), manufacturing smooth muscle mass leisure inside the corpus cavernosum and making it possible for inflow of blood .

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The physiological mechanism accountable for the erection amıncocugu with the penis will involve the release of nitric oxide (NO) from the corpus cavernosum through sexual stimulation .

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